Regina Alice Doyle was born on September 2, 1907 in Chicago, Illinois. Her father, John Doyle, was a fireman. Regina was educated at the Grenshaw Conservatory. Her family moved to Los Angeles when she was seventeen. On July 2, 1925 Regina married thirty-one year old Stewart Gilbert Cornelius. They had one child together and divorced in 1927. By this time Regina was pursing an acting career. She appeared in several western shorts including The Lone Prairie and The Scrapping Ranger. In 1929 she was given the lead opposite Edmund Cobb in Beyond The Smoke. They would make three more films together.
Regina seemed destined for stardom but after several years at Universal Studios she stopped making movies in 1930. On September 29, 1931 Regina crashed her car into a freight train on Highland Avenue in Hollywood. She was thrown from the car and died almost instantly. Regina was only twenty-four years old. The coroner ruled that the accident was caused by reckless driving. She is buried at Calvary Cemetery in Los Angeles. Just a few days before Regina's death her mother had a premonition something terrible was going to happen. She warned her daughter to "Drive slowly".